Enhancement of Methyldopa Metabolism with Barbiturate
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چکیده
منابع مشابه
Enhancement of methyldopa metabolism with barbiturate.
The spurious increase in serum catecholamine levels associated with methyldopa treatment can be reduced by the simultaneous administration of phenobarbitone. This accelerating effect of phenobarbitone on methyldopa metabolism has been demonstrated in relation to both adrenaline and noradrenaline, and investigations suggest that it is due to the effect of barbiturate on the activity of metaboliz...
متن کاملStudies on the Metabolism and Mechanism of Action of Methyldopa.
THE decarboxylase-inhibiting, sedative, and antihypertensive properties of amethyl-3,4-dihydroxy-DI,-phenylalanine (DL-amethyl-dopa) in man were first reported from this department in 1960.1 It was shown subsequently that these three properties of the compound reside solely in the L isomer (methyldopa, Aldomet) .2, 3 Numerous favorable reports on the use of methyldopa in the treatment of hypert...
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A hydrogen-bonding interaction between phenobarbital or pentobarbital with phosphatidylcholine in chloroform is indicated by the effects of added phosphatidylcholine on the infrared and proton magnetic resonance spectra of these barbiturates. The nitrogenbound proton of the barbiturate and the orthophosphate moiety of the phosphatidylcholine molecule appear to be involved. The more pronounced e...
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Drug-metabolizing capacity has been assessed by serial measurements of the plasma antipyrine half life in 11 patients with severe barbiturate intoxication and in 17 patients with acute hepatic necrosis due to paracetamol overdosage. Drug metabolism was strikingly enhanced after barbiturate over-dosage, and this effect was still present six weeks later. In contrast the antipyrine half life was g...
متن کاملCollagen metabolism and reversal of aortic medial hypertrophy in spontaneously hypertensive rats treated with methyldopa.
Collagen synthesis, content, and concentration were determined in the hypertrophied intima media of thoracic aortas from 10-, 15-, and 20-week-old spontaneously hypertensive rats (SHR). Although the rates of aortic collagen synthesis declined with age, the dry weight of the intima media and the total collagen content increased proportionally. Collagen concentration thus remained unchanged. Meth...
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ژورنال
عنوان ژورنال: BMJ
سال: 1971
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.3.5773.518